• STELARA^® is a human IgG1k  monoclonal antibody that binds with specificity to the p40 protein subunit used by both the interleukin (IL)-12 and IL-23 cytokines¹
• IL-12 and IL-23 are naturally occurring cytokines that are involved in inflammatory and immune responses, such as natural killer cell activation and CD4+ T-cell differentiation and activation¹
• In in vitro models, STELARA® was shown to disrupt IL-12– and IL-23–mediated signaling and cytokine cascades by disrupting the interaction of these cytokines with a shared cell-surface receptor chain, IL-12Rβ1¹
• The clinical significance of these characteristics is not fully known

Reference: 1. STELARA^® Prescribing Information. Horsham, PA: Janssen Biotech, Inc.