STELARA® Targets an Inflammatory Gateway of Crohn’s Disease1-7
By Targeting the Upstream* Regulatory Cytokines IL-12 and IL-23, STELARA® May Be Able to Disrupt the Resulting Inflammatory Cascade
The clinical significance of these characteristics is not fully known
*Ustekinumab is a human IgG1k monoclonal antibody that binds with specificity to the p40 protein subunit used by both the IL-12 and IL-23 cytokines. IL-12 and IL-23 are naturally occurring cytokines that are involved in inflammatory and immune responses, such as natural killer cell activation and CD4+ T-cell differentiation and activation. In in vitro models, ustekinumab was shown to disrupt IL-12 and IL-23 mediated signaling and cytokine cascades by disrupting the interaction of these cytokines with a shared cell-surface receptor chain, IL-12Rß1. The cytokines IL-12 and IL-23 have been implicated as important contributors to the chronic inflammation that is a hallmark of Crohn’s disease.
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